C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 41/00 (2006.01) A61K 8/14 (2006.01) A61K 9/127 (2006.01) A61K 31/575 (2006.01) A61K 31/58 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07J 43/00 (2006.01)
Patent
CA 2702103
An amphoteric liposome comprising neutral lipids wherein said neutral lipids are selected from the group comprising cholesterol or mixtures of cholesterol and at least one neutral or zwitterionic lipid and wherein K (neutral) of said mixtures is 0.3 or less. Said amphoteric liposome may encapsulate an active agent, such as nucleic acid therapeutics. Also disclosed are pharmaceutical compositions comprising said amphoteric liposomes as a carrier for the delivery or targeted delivery of active agents or ingredients.
L'invention concerne un liposome amphotère comprenant des lipides neutres, lesdits lipides neutres étant choisis dans le groupe constitué par du cholestérol ou des mélanges de cholestérol et d'au moins un lipide neutre ou zwitterionique, et la K (neutre) desdits mélanges étant de 0,3 ou moins. Ledit liposome amphotère peut encapsuler un agent actif, tel qu'un produit thérapeutique d'acide nucléique. L'invention porte également sur des compositions pharmaceutiques comprenant lesdits liposomes amphotères en tant que support pour l'administration ou l'administration ciblée d'agents ou ingrédients actifs.
Lutz Silke
Muller Claudia
Panzner Steffen
Siepi Evgenios
Vinzens Ute
Blake Cassels & Graydon Llp
Marina Biotech Inc.
Novosom Ag
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