Improvements in or relating to contrast agents

Details Improvements in or relating to contrast agents Improvements in or relating to contrast agents

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 49/22 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2246779

Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble--containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble--containing contrast agent.

Cette invention concerne des dispersions contenant des microbulles stabilisées par des phospholipides comprenant majoritairement des molécules qui possèdent individuellement une charge nette globale. Ces dispersions présentent une stabilité avantageuse, ce qui les rend très utiles en tant que milieux de contraste. L'invention concerne également un procédé perfectionné de préparation de milieux de contraste contenant des microbulles, ledit procédé consistant à lyophiliser une dispersion aqueuse de microbulles de gaz stabilisées par au moins un lipide capable de former une membrane, de façon à obtenir un produit sec qui peut être reconstitué dans un liquide porteur injectable, afin de générer un milieu de contraste contenant des microbulles.

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