Improvements in or relating to delivery of nucleic acid

Details Improvements in or relating to delivery of nucleic acid Improvements in or relating to delivery of nucleic acid

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 47/04 (2006.01) A61K 48/00 (2006.01) C12N 15/87 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2227770

Disclosed are various compositions for use in the delivery of nucleic acid to a target cell including: a composition comprising a calcium salt in particulate form, the nucleic acid to be delivered, and one or more further components to enhance the efficiency of delivery of the nucleic acid to a target cell, the nucleic acid and the one or more further components being complexed with the particulate calcium salt; and methods of delivering a nucleic acid to a target cell.

Cette invention concerne diverses compositions pouvant être utilisées dans l'apport d'acide nucléique à une cellule cible, lesquelles comprennent: une composition contenant un sel de calcium sous forme particulaire, l'acide nucléique devant être apporté, et un ou plusieurs autres composants permettant d'accroître l'efficacité de l'apport en acide nucléique à une cellule cible. L'acide nucléique ainsi que le ou les autres composants sont complexés avec le sel de calcium particulaire. Cette invention concerne également des procédés d'apport d'acide nucléique à une cellule cible.

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