A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 41/00 (2006.01) A61K 49/04 (2006.01) A61K 51/12 (2006.01) C07K 4/00 (2006.01)
Patent
CA 2329778
Novel membrane-forming amphiphilic lipopeptides comprising one or more peptide moieties containing 2-50 aminoacyl residues and one or more hydrocarbon chains containing 5-50 carbon atoms. Such lipopeptides may be used in the formation of stabilised gas microbubble dispersions suitable for use as diagnostic and/or therapeutic agents, for example as ultrasound contrast agents.
L'invention se rapporte à de nouveaux lipopeptides amphiphiles, formateurs de membrane, qui comportent une ou plusieurs fractions peptidiques contenant 2 à 50 restes aminoacyle et une ou plusieurs chaînes hydrocarbonées contenant 5 à 50 atomes de carbone. Ces lipopeptides peuvent être utilisés pour la formation de dispersions de microbulles de gaz stabilisées pouvant servir d'agents diagnostiques et/ou thérapeutiques, et notamment d'agents de contraste pour dispositifs à ultrasons.
Cuthbertson Alan
Solbakken Magne
Wolfe Henry Raphael
Amersham Health As
Fetherstonhaugh & Co.
Nycomed Imaging As
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