Improvements in or relating to haemoglobin

Details Improvements in or relating to haemoglobin Improvements in or relating to haemoglobin

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A61K 38/42 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2170638

Disclosed is a .beta. globin modified so as to exhibit, when present as part of a haemoglobin molecule, an altered bicarbonate effect compared to the unmodified .beta. globin, the modification comprising alteration of at least two of the amino acid residues in the group consisting of residues (29-41), and a haemoglobin molecule comprising said .beta. globin, with or without further modifications to the .alpha. globin component thereof.

On a décrit une beta -globine modifiée de manière à présenter, lorsqu'elle fait partie d'une molécule d'hémoglobine, un effet bicarbonate modifié par comparaison avec la beta globine non modifiée, la modification portant sur au moins deux des acides aminés dans le groupe constitué des acides aminés (29-41). L'invention concerne également une molécule d'hémoglobine contenant ladite beta -globine, avec ou sans d'autres modifications de son composant alpha -globine.

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