A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61P 1/00 (2006.01) A61P 19/02 (2006.01)
Patent
CA 2586708
A pharmaceutical composition is disclosed, which composition comprises an oligonucleotide as an active agent, the oligonucleotide being adapted to target nucleic acids encoding CD40 thereby to modulate the expression of CD40 in mammalian cells, and a liposome as an excipient. Said liposome is an amphoteric liposome. Also disclosed is a method for the treatment or prophylaxis of a disease or condition associated with the expression of CD40 in a human or non-human animal patient by administering to said patient a therapeutically or prophylactically effective amount of such a composition.
L'invention concerne une composition pharmaceutique comprenant un oligonucléotide comme agent actif, l'oligonucléotide étant utilisé pour cibler des acides nucléiques cibles codant pour CD40 afin de moduler l'expression de CD40 dans des cellules mammifères, ainsi qu'un liposome utilisé comme excipient. Ce liposome est un liposome amphotère. L'invention concerne également une méthode destinée au traitement ou à la prévention d'une maladie ou d'un trouble associé à l'expression de CD40 chez un être humain ou un animal, consistant à administrer au patient une dose thérapeutique ou préventive de ladite composition.
Braeuer Rolf
Endert Gerold
Fankhaenel Stefan
Gao Dingcheng
Hecker Markus
Blake Cassels & Graydon Llp
Novosom Ag
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