Improvements in or relating to powders

A - Human Necessities – 61 – K

Patent

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A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/72 (2006.01)

Patent

CA 2353448

Particles of an amino acid such as leucine may be formed from an amino acid vapour, for example by aerosol condensation, or by spray drying. The amino acid particles have a bulk density of not more than 0.1 gcm-3 or have a mass median aerodynamic diameter of not more than 10 µm or are in the form of flakes having a thickness of not more than 100 .um.m. The inclusion of the particles of amino acid in powder for use in dry powder inhalers has been found to improve the respirable fraction of the active material in the powder.

L'invention concerne des particules d'un acide aminé tel que la leucine qui peuvent constituées d'une vapeur d'acide aminé, par exemple par condensation en aérosol, ou par séchage par atomisation. Les particules d'acide aminé présentent un poids volumique apparent ne dépassant pas 0,1 gcm<-3> ou un diamètre aérodynamique moyen en masse ne dépassant pas 10 mu m. Ces particules d'acide aminé peuvent également se présenter sous la forme de flocons présentant une épaisseur ne dépassant pas 100 mu m. On a découvert que l'inclusion de ces particules d'acide aminé dans une poudre destinée à des inhalateurs à poudre sèche améliore la fraction respirable de la matière active dans la poudre.

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