Improvements in or relating to regulation of t cell activation

Details Improvements in or relating to regulation of t cell activation Improvements in or relating to regulation of t cell activation

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2303617

Disclosed is a method of making a leukocyte differentially reactive to different densities of leukocyte-stimulating molecules present on the surface of a cell, wherein the leukocyte is activated by an interaction between the leukocyte-stimulating molecule on the cell and a leukocyte-activating molecule present on the surface of the leukocyte, the method comprising: transforming the leukocyte with a nucleic acid sequence directing the expression of the leukocyte-activating molecule in a manner sensitive to the concentration of an exogenous agent; and altering the concentration of exogenous agent to which the leukocyte is exposed.

L'invention porte sur un procédé permettant de faire réagir différentiellement un leucocyte à différentes densités de molécules stimulatrices de leucocytes présentes à la surface d'une cellule. L'activation du leucocyte est due à une interaction entre une molécule stimulatrice des leucocyte, présente sur la cellule, et une molécule activatrice de leucocytes, présente à la surface du leucocyte. Le procédé consiste à transformer le leucocyte à l'aide d'une séquence d'acide nucléique en influant sur l'expression de la molécule activatrice de leucocytes pour la rendre sensible à la concentration d'un agent exogène, puis à modifier la concentration de l'agent exogène auquel le leucocyte est exposé.

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