Improvements in or relating to skin dressings

A - Human Necessities – 61 – L

Patent

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Details

A61L 15/38 (2006.01) A61L 15/60 (2006.01)

Patent

CA 2554191

A skin dressing of the general form disclosed in WO 03/030800 comprises oxidoreductase enzyme in hydrated condition in a hydrated hydrogel of hydrophilic polymer material, wherein hydrogel comprises at least 25 % by weight of the polymer material. A currently preferred dressing comprises a lower, skin-contacting layer (18) comprising a hydrated hydrogel comprising 30 % by weight sodium poly-AMPS and 5 % by weight glucose, and an upper layer (16) comprising a hydrated hydrogel comprising 15% by weight sodium poly-AMPS, 15 % by weight ammonium poly-AMPS, and glucose oxidase. Using hydrogels with a higher concentration of polymer material is found to affect the rate of oxygen generation and hence the oxygen concentration profile beneath the dressing in use in a manner beneficial to wound healing.

Le pansements dermiques de la forme générale présenté dans WO 03/030800 comprend une oxydoréductase à l'état hydratée dans un hydrogel hydraté de matériau polymère hydrophile, l'hydrogel représentant au moins 25 % en poids du polymère. Une variante préférée de ce pansement comporte: une couche inférieure (18) en contact avec la peau comprenant un hydrogel hydraté contenant 30 % en poids de poly-AMPS de sodium et 5 % en poids de glucose; et une couche supérieure (16) comprenant un hydrogel hydraté contenant 15 % en poids de poly-AMPS de sodium, 15 % en poids de poly-AMPS d'ammonium, et une glucose oxydase. On a découvert que l'utilisation d'hydrogels à plus forte concentration de matériau polymère accroissait la vitesse de production d'oxygène, donc le profil de concentration en oxygène sous le pansement, et favorisait la cicatrisation.

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