Improvements in platinum complexes

Details Improvements in platinum complexes Improvements in platinum complexes

C - Chemistry, Metallurgy

07

F

C07F 15/00 (2006.01) A61K 31/28 (2006.01) A61K 31/555 (2006.01)

Patent

CA 2169019

Platinum complexes of formula Ia or Ib Image Ia Image Ib where each A, is a leaving group and may be the same or different, which is suitably halo, especially chloro, hydroxy, carboxylate or together form a bi-dentate carboxylate or sulphate, each B, which may be the same or different, is halo, hydroxy, carboxylate, carbamate or carbonate ester, Z is a substituted amine wherein the substituent sterically hinders access of the Pt atom to a DNA strand of a tumour cell, and X is NH3 or mono- or di-alkyl substituted NH3, are active against cancer cells, and appear to show a unique form of chemical and biological action.

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