Improvements in production of proteins in host cells

Details Improvements in production of proteins in host cells Improvements in production of proteins in host cells

C - Chemistry, Metallurgy

12

N

C12N 15/67 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C12N 15/12 (2006.01) C12N 15/79 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2198345

Method of increasing protein production in a host cell where the nucleic acid encoding the protein has an A and/or T rich region in an exon. The method comprising lowering the amount of A and/or T rich region and transfecting a host cell with the altered nucleic acid and obtaining expression of the nucleic acid. The invention also relates to the recombinant nucleic acid constructs, purified protein preparations and pharmaceutical compositions produced as well as methods of treatment utilizing the purified protein preparation.

Procédé d'accroissement de la production de protéine dans une cellule hôte dans laquelle l'acide nucléique codant la protéine comporte une région riche en A et/ou T présente dans un exon. La méthode consiste à abaisser la teneur en A et/ou en T dans la région riche en A et/ou en T puis à transfecter une cellule hôte avec l'acide nucléique modifié pour obtenir l'expression de l'acide nucléique. L'invention porte également sur des constructions d'acide nucléique de recombinaison, des préparations et des compositions pharmaceutiques à base de protéine purifiée ainsi que sur des méthodes de traitement mettant en oeuvre de telles préparations.

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