Improvements relating to anti-hiv tablet formulations

Details Improvements relating to anti-hiv tablet formulations Improvements relating to anti-hiv tablet formulations

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/36 (2006.01) A61K 31/34 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2693235

An anti-HIV tablet formulation comprising a core containing 0.1 to 1.5% by weight (w/w) of colloidal silicon dioxide and 0.4 to 0.9% by weight (w/w) of a lubricant, the balance of the core comprising darunavir, a disintegrant and a filler comprising a spray-dried mixture of microcrystalline cellulose and colloidal silicon dioxide, the core being optionally coated with a film coating.

La présente invention concerne une formulation de comprimé anti-VIH comprenant un noyau. Ledit noyau contient de 0,1 à 1,5 % en poids (p/p) de dioxyde de silicone colloïdale, et de 0,4 à 0,9 % en poids (p/p) d'un lubrifiant. Le reste du noyau comprend du darunavir, un délitant et une charge contenant un mélange desséché par nébulisation de cellulose microcristalline et de dioxyde de silicone colloïdale. Ledit noyau est éventuellement recouvert d'un pelliculage.

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