A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A01N 31/16 (2006.01) A01N 37/50 (2006.01) A01N 43/653 (2006.01) A01N 53/00 (2006.01)
Patent
CA 2656217
The invention provides process for making contra-soluble nano-dispersions of at most sparingly-soluble materials in a soluble carrier material comprising the steps of: (i) providing a single phase mixture of: a) a solvent or a mixture of miscible solvents, b) at least one carrier material soluble in solvent (a), said carrier material being also contra-soluble to payload material (c) and solid at ambient temperature, c) at least one a payload material which is soluble in solvent (a), and, (ii) drying the mixture to remove solvent (a) and thereby obtain the carrier material (b) in solid form with payload (c) dispersed therein as nanoparticles.
La présente invention concerne un procédé de fabrication de nanodispersions anti-solubles de substances très peu solubles dans une matière de support soluble comprenant les étapes suivantes : (i) la mise à disposition d'un mélange à simple phase : a) d'un solvant ou d'un mélange de solvants miscibles, b)d'au moins une matière de support soluble dans le solvant (a), ladite matière de support étant également contra-soluble à la substance de charge (c) et solide à la température ambiante, c) d'au moins une substance de charge qui est soluble dans le solvant (a); et (ii) le séchage du mélange pour éliminer le solvant (a) et obtenir ainsi la matière de support (b) sous forme solide avec la substance de charge (c) dispersée dans celle-ci sous la forme de nanoparticules.
Angus Doris
Duncalf David John
Elphick Andrew James
Foster Alison Jayne
Long James
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Plc Unilever
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