Improvements relating to pharmaceutical compositions

A - Human Necessities – 61 – K

Patent

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A61K 9/16 (2006.01) A61K 31/366 (2006.01)

Patent

CA 2659666

A process for the production of a composition comprising a water-insoluble statin which comprises the steps of: a) providing a mixture comprising: i) a water-insoluble statin ii) a water soluble carrier, iii) a solvent for each of the statin and the carrier, and b) spray-drying the mixture to remove the or each solvent and obtain a substantially solvent-free nano-dispersion of the statin in the carrier.

L'invention concerne un procédé de production d'une composition comprenant une statine insoluble dans l'eau, consistant a) à former un mélange contenant i) une statine insoluble dans l'eau, ii) un excipient soluble dans l'eau et iii) un solvant pour la statine et un autre pour l'excipient, et b) à sécher par pulvérisation le mélange pour éliminer le solvant ou chaque solvant et obtenir dans l'excipient une nano-dispersion de statine sensiblement exempte de solvant.

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