C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 17/10 (2006.01) A61K 31/195 (2006.01) A61K 31/365 (2006.01) A61K 31/55 (2006.01) A61K 38/05 (2006.01) A61K 47/48 (2006.01) C07D 207/46 (2006.01) C07D 243/24 (2006.01) C07K 5/06 (2006.01) C12P 17/16 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2167480
The present invention provides a prodrug of the general formula FTLi-(PRT)m, where FTLi is a ras inhibitor such as a famesyltransferase inhibitor compound and PRT represents m protecting groups capable of being cleaved from the ras inhibitor by the action of an enzyme, where m is an integer from 1 to 5.
La présente invention concerne un promédicament de la formule générale FTLi-(PRT)m, dans laquelle FTLi représente un inhibiteur de ras tel qu'un composé inhibiteur de farnésyltransférase et PRT représente m groupes protecteurs pouvant se séparer de l'inhibiteur de ras sous l'action d'une enzyme, m étant un nombre entier pouvant aller de 1 à 5.
Marais Richard
Springer Caroline Joy
Cancer Research Campaign Technology Limited
Mccarthy Tetrault Llp
LandOfFree
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