C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2285221
This invention seeks to improve the specificity of gene expression by targeting a specific expression site of a target gene. There is thus provided a chimaeric gene which comprises a promoter which expresses in more than one region of the organism to be affected. The promoter is linked to an agent which affects the functioning of an endogenous gene in the plant which is also expressed in more than one region of the plant. The promoter and agent are selected so that there is an overlap in their expression sites at one or more desired locations. This overlap site(s) gives increased specificity and targeting of gene expression.
Grâce à cette invention, on cherche à améliorer la spécificité de l'expresssion génétique en ciblant un site spécifique d'un gène cible. On produit ainsi une chimère qui comprend un promoteur qui exprime dans plus d'une régiob de l'organisme devant être affecté. Ce promoteur est lié à un agent qui affecte le fonctionnement d'un gène endogène de la plante qui est aussi exprimé dans plus d'une région de la plante. Le promoteur et l'agent sont sélectionnés de manière à ce qu'il y ait un recouvrement de leurs sites d'expression dans un ou plusieurs endroits recherchés. Ce ou ces sites de recouvrement donnent une spécificité et un ciblage de l'expression générique acccrus.
O'reilly David
Thomas Christopher John Robert
Advanced Technologies (cambridge) Limited
Fetherstonhaugh & Co.
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