Imunogenic conjugate of carbohydrate haptens and aggregated...

Details Imunogenic conjugate of carbohydrate haptens and aggregated... Imunogenic conjugate of carbohydrate haptens and aggregated...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/715 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 49/00 (2006.01) C07K 14/435 (2006.01) C12N 9/10 (2006.01) C12N 9/20 (2006.01) D21C 3/00 (2006.01)

Patent

CA 2454853

A conjugate of a plurality of carbohydrate haptens and an aggregate (multimer) of monomeric units of a carrier moiety is provided. The conjugate may be used to elicit an immune response. The conjugate is preferably a carbohydrate- substituted aggregate of KLH monomers, in particular, a dimeric, trimeric or tetrameric aggregated. An aggregated STn-KLH conjugate is of particular interest.

L'invention concerne un conjugué de plusieurs haptènes glucidiques et un agrégat (multimère) d'unités monomères d'une fraction véhicule. Le conjugué peut servir à éliciter une réponse immune. Le conjugué est, de préférence, un agrégat de monomères KLH substitué par des glucides, en particulier un dimère, un trimère ou tétramère agrégé. Un conjugué agrégé STn-KLH présente un intérêt particulier.

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