C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) C07K 14/435 (2006.01)
Patent
CA 2695951
The present invention encompasses a method for the production of Apolipopro-teins in dimeric and/or oligomeric forms (comprising three or more units) of muteins of the human ApoA-1 protein in plant seeds, novel variants of these proteins having an increased stability and capacity to transport cholesterol compared to the native ApoA-1 protein, expression systems for the production thereof, plants transformed capable of producing said proteins in seeds in dimeric and/or oligomeric forms, and nutraceutical derivatives of these plants.
La présente invention concerne un procédé de production d'apolipoprotéines sous des formes dimères et/ou oligomères (comprenant trois unités ou plus) de mutéines de la protéine ApoA-1 humaine dans des graines de végétaux, des variantes innovantes de ces protéines ayant une stabilité et une capacité à transporter le cholestérol meilleures que celles de la protéine ApoA-1 native, des systèmes d'expression pour leur production, des végétaux transformés dont les graines sont capables de produire lesdites protéines sous des formes dimères et/ou oligomères et des dérivés nutraceutiques de ces végétaux.
Fogher Corrado
Perfanov Kiril
Reggi Serena
Borden Ladner Gervais Llp
Plantechno S.r.l.
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