In situ modification of alginate

Details In situ modification of alginate In situ modification of alginate

A - Human Necessities

61

L

A61L 31/04 (2006.01) A61L 25/00 (1990.01) A61K 31/725 (1990.01)

Patent

CA 2139311

A method of modifying salts of alginic acid in situ for prevention and treatment of various intra-articular and extra-articu- lar (spine) complications modifies the alginate in situ to an insoluble gel. This in situ modification provides a final product which can be compressed within the intra-articular space thus remaining localized. The modified material can have varied mechanical strengths and thus varied degradation times and can serve as a matrix for localizing and slowly releasing therapeutic agents. The modified material is biocompatible and biodegrable, thus requiring no reoperation for removal.

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