In situ system for intra-articular chondral and osseous...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/20 (2006.01) A61F 2/30 (2006.01) A61L 27/24 (2006.01) A61L 27/58 (2006.01)

Patent

CA 2674524

Disclosed is a device and method which provide a surgical therapy for in situ treatment and repair of intra-articular cartilage lesions and/or defects. The device is an implantable laminate cartilage repair patch which is bio-compatible and physiologically absorbable. The cartilage repair patch has a first outer cell occlusive layer; a second outer, cell porous layer adapted to be disposed proximate a subchondral bone wound site; and a cartilagenic matrix disposed between the first and second layers. The cartilagenic matrix is a sink for diffusion of autologous stem cells and includes chemical components promoting generation of hyaline-like cartilage in the presence of the autologous stem cells. The method of the present invention provides the autologous compositions, which when used in combination with the repair patch provides a therapeutic system to regenerate replacement hyaline-like intraarticular cartilage.

L'invention concerne un dispositif et un procédé qui font appel àune thérapie chirurgicale pour un traitement in situ et une réparation de lésions et/ou de défauts du cartilage intra-articulaire. Le dispositif est une pièce stratifiée implantable, pour la réparation du cartilage, qui est biocompatible et physiologiquement absorbable. La pièce pour la réparation du cartilage a une première couche occlusive cellulaire, externe; une seconde couche poreuse cellulaire, externe, apte à être disposée à proximité d'un site de plaie osseuse sous-chondrale; et une matrice de cartilage disposée entre les première et seconde couches. La matrice de cartilage est un puits pour la diffusion de cellules souches autologues et comprend des composants chimiques favorisant la génération de cartilage de type hyalin en présence des cellules souches autologues. Le procédé de la présente invention utilise les compositions autologues, lesquelles, lorsqu'elles sont utilisées en combinaison avec la pièce de réparation, fournissent un système thérapeutique pour régénérer un cartilage intra-articulaire de type hyalin de remplacement.

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