In-vial deposition of 7-(dimethylaminomethylene)...

Details In-vial deposition of 7-(dimethylaminomethylene)... In-vial deposition of 7-(dimethylaminomethylene)...

A - Human Necessities

61

K

167/240, 260/298

A61K 31/395 (2006.01) A61K 31/40 (2006.01) C07D 487/14 (2006.01)

Patent

CA 1262097

Abstract of the Disclosure There is disclosed a process for the in-vial deposition of 7-(dimethylaminomethylene)amino-9a-methoxy- mitosane in sterile unit dosage form. A solution of this compound is introduced into a sterile vial is a solution of tertiary-butanol. The tertiary-butanol is then re- moved, e.g., by evaporation or lyophilization, and the vial is closed by appropriate means. The thus deposited material can contain up to 0.5 mole equivalent of tertiary- butanol as a hemi-solvate and is very stable to heat.

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