C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A61K 31/00 (2006.01) A61K 31/05 (2006.01) A61K 31/11 (2006.01) A61K 31/565 (2006.01) A61K 31/567 (2006.01) A61K 38/29 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2346459
The present invention demonstrates that glucocorticoid-induced bone disease is due to changes in the birth and death rate of bone cells using a murine model of glucocorticoid excess as well as bone biopsy specimens obtained from patients with glucocorticoid-induced osteoporosis. This invention demonstrates that glucocorticoid administration increases apoptosis of mature osteoblasts and osteocytes and decreases bone formation rate and bone mineral density accompanied by defective osteoblastogenesis and osteoclastogenesis in the bone marrow.
La présente invention vise à démontrer que la destruction osseuse induite par les glucocorticoïdes est due à des modifications des taux de naissance et de mort des cellules osseuses au moyen d'un modèle murin d'excès de glucocorticoïdes et de biopsies osseuses pratiquées sur des patients atteints d'ostéoporose induite par les glucocorticoïdes. Cette invention démontre que l'administration de glucocorticoïdes accroît l'apoptose des ostéocytes et des ostéoblastes matures et réduit la vitesse de formation osseuse et la densité minérale osseuse associée à des troubles de l'ostéoclastogenèse et de l'ostéoblastogenèse dans la moelle épinière.
Bellido Teresita
Jilka Robert L.
Manolagas Stavros C.
Weinstein Robert S.
Hughes Ivor M.
The Board Of Trustees Of The University Of Arkansas
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