C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/70 (2006.01) A61K 39/23 (2006.01) A61K 39/42 (2006.01) A61K 49/00 (2006.01) C07K 16/08 (2006.01) C12Q 1/04 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2422635
The present invention provides an assay for measuring the immunogenicity of a vaccine, wherein the vaccine contains an epitope having a conformation associated with an immunogenically active form of the vaccine and a fragment having a conformation associated with an immunogenically inactive form of the vaccine, wherein the method includes exposing a sample of the vaccine to a first ligand capable of binding to the epitope in the conformation associated with the immunogenically active form of the vaccine and a second ligand capable of binding to the fragment in the conformation associated with the immunogenically inactive from of the vaccine and measuring the amount of first ligand bound to the vaccine sample and the amount of the second ligand bound to the vaccine sample.
La présente invention concerne un dosage destiné à mesurer l'antigénicité d'un vaccin. Ce vaccin contient un épitope présentant une conformation associée à une forme immunogène active de ce vaccin et un fragment possédant une conformation associée à une forme immunogène inactive de ce vaccin. Cette technique consiste à exposer un échantillon de ce vaccin à un premier ligand capable de se lier à l'épitope dans la conformation associée à la forme immunogène active de ce vaccin, et à un second ligand capable de se lier au fragment dans la conformation associée à la forme immunogène inactive de ce vaccin, et à mesurer la quantité du premier ligand lié à l'échantillon de ce vaccin et la quantité du second ligand lié à l'échantillon de ce vaccin.
Schenerman Mark A.
Strouse Robert J.
Suzich Joann
Wang Sheau-Chiann
White Wendy I.
Medimmune Inc.
Smart & Biggar
LandOfFree
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