In vitro assay for testing gabapentinoid activity

Details In vitro assay for testing gabapentinoid activity In vitro assay for testing gabapentinoid activity

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2369477

An assay and method for selecting analogs and derivatives of gabapentin based on the compounds inhibitory activity toward MAP kinase and MAP kinase mediated reporter gene expression. The method includes the steps of activating the MAP kinase signaling pathway, detecting the MAP kinase signal, and screening the gabapentin analogs and derivatives for inhibitory activity against the MAP kinase signal.

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