In vitro cultured ligament tissue and method of making same

Details In vitro cultured ligament tissue and method of making same In vitro cultured ligament tissue and method of making same

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 35/32 (2006.01) A61L 27/00 (2006.01) A61L 27/24 (2006.01) A61L 27/38 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2285161

An implantable tendon-like or ligament-like tissue construct involving the creation of a tissue from a composite of a donor or source scaffold derived from allograft, autograft or xenograft of collagen fibers and directly seeded ligament or tendon fibroblasts. The fibroblasts are host derived, expanded in vitro, and are seeded directly on the scaffold. Following initial seeding, secondary collagen seeding is performed around the scaffold, which allows the delivery of high numbers of fibroblasts and sufficient collagen for these cells to rapidly produce a ligament or tendon-like tissue material in vitro. The construct is cultured in vitro for a sufficient period of time to allow cell mediated matrix organization and integration, after which the construct may be implanted at the desired host site. Most preferably, a rat tail tendon is selected as the source xenograft for the collagen fiber scaffold.

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