In vitro-derived human neutrophil precursor cells

Details In vitro-derived human neutrophil precursor cells In vitro-derived human neutrophil precursor cells

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61K 48/00 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2109729

2109729 9318648 PCTABS00025 A composition comprising human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16 % human myeloblasts and promyelocytes, which have been derived from neutrophil progenitor cells obtained from peripheral blood, bone marrow or cord blood, and less than about 5 % colony forming units (CFU) of at least about 50 cells is provided. An alternative composition comprising human neutrophil precursor cells, wherein the cellular component is comprised of at least about 16 % CD15+CD11b- cells and less than about 5 % colony forming units (CFU) of at least about 50 cells also is provided, wherein at least about 60 % of the CD15+CD11b- cells are myeloblasts and promyelocytes.

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