In vitro formation of congophilic maltese-cross amyloid...

Details In vitro formation of congophilic maltese-cross amyloid... In vitro formation of congophilic maltese-cross amyloid...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/16 (2006.01) C07K 1/10 (2006.01) C07K 1/113 (2006.01) G01N 33/50 (2006.01) C07K 17/02 (2006.01) C07K 19/00 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2323090

The invention describes the formation of amyloid plaques by coincubation of an amyloid protein with sulfated macromolecules such as perlecan. The resulting plaques may be stained with congo red and demonstrate a maltese-cross pattern when viewed under polarized light. Alternatively the plaques may be stained with Thioflavin S when under fluorescence microscopy.

L'invention se rapporte à la formation de plaques amyloïdes par co-incubation d'une protéine amyloïde avec des macromolécules sulfatées du type perlécane. Les plaques résultantes peuvent être colorées avec du rouge Congo et présentent la forme d'une croix de malte qu'il est possible d'observer sous une lumière polarisée. Les plaques peuvent également être colorées avec de la Thioflavine S pour l'observation par microscopie par fluorescence.

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