A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/39 (2006.01) C07K 14/62 (2006.01) C12P 21/02 (2006.01) A61K 35/12 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2188648
The subject invention concerns new methods which make it possible, for the first time, to grow functional islets in in vitro cultures. The subject invention also concerns the use of the in vitro grown islets-like structures for implantation into a mammal for in vivo therapy of diabetes. The subject invention further concerns a process using the in vitro grown islet implants for growing an organ in vivo that has the same functional, morphological and histological characteristics as those observed in normal pancreatic tissue. The ability to grow these cells in vitro and organs in vivo opens up important new avenues for research and therapy relating to diabetes.
L'invention concerne de nouveaux procédés qui permettent pour la première fois de faire pousser des îlots fonctionnels dans des cultures in vitro. La présente invention concerne également l'utilisation des structures apparentées aux ilôts cultivés in vitro en vue de leur implantation chez un mammifère comme thérapie du diabète. L'invention traite également d'un procédé utilisant les implants d'îlots cultivés in vitro pour faire pousser un organe in vivo qui présente les mêmes caractéristiques fonctionnelles, morphologiques et histologiques que celles observées dans le tissu pancréatique normal. La possibilité de faire pousser ces cellules in vitro et ces organes in vivo ouvre de nouvelles perspectives importantes pour la recherche et la thérapie relatives au diabète.
Cornelius Janet G.
Peck Ammon B.
Cornelius Janet G.
Peck Ammon B.
Sim & Mcburney
University Of Florida Research Foundation Inc.
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