In vitro human angiogenesis model

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/071 (2010.01) A61L 27/38 (2006.01) C12Q 1/02 (2006.01) A61K 35/44 (2006.01)

Patent

CA 2418077

The present invention relates to a tridimensional living tissue construct free of exogenous extracellular matrix material, and in which angiogenesis occurs. Network of capillaries formed into the living tissue construct allows to provide blood vessels for replacement or repair in human and animals, and is also useful in screening compounds or agents potentially having capability of modulating the angiogenesis in vitro or in vivo.

La présente invention concerne une structure tissulaire vivante tridimensionnelle qui est dépourvue de matière matricielle extracellulaire exogène, et dans laquelle se déroule l'angiogenèse. Un réseau de capillaires formé dans la structure tissulaire vivante permet de former des vaisseaux sanguins destinés à servir de remplacement ou de réparation chez les êtres humains et chez les animaux. Ledit réseau s'avère également utile pour sélectionner des composés ou des agents ayant potentiellement l'aptitude de moduler l'angiogenèse in vitro ou in vivo.

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