A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) C12N 7/04 (2006.01) G01N 31/00 (2006.01)
Patent
CA 2394052
A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be used to encapsulate desired moieties, e.g., therapeutic or diagnostic agents, or "marker" DNAs, and the resultant VLPs used as in vivo delivery vehicles or as pseudovirions for evaluating vaccine efficacy.
L'invention concerne une méthode de désassemblage-réassemblage de particules voroïdes du papillomavirus. Les VLP ainsi obtenues présentent une homogénéité accrue, ainsi que des épitopes de papillomavirus neutralisants, conformationnels, et constituent, par conséquent, des agents prophylactiques et diagnostiques utiles. En outre, on peut utiliser ces VLP pour encapsuler des fractions voulues, par exemple, des agents thérapeutiques ou diagnostiques, ou des AND "marqueurs", et les VLP obtenues utilisées comme vecteurs d'administration in vivo ou comme pseudovirions permettant d'évaluer l'efficacité d'un vaccin.
Mccarthy Michael P.
Suzich Joanne A.
Medimmune Inc.
Smart & Biggar
LandOfFree
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