In vitro method for disassembly/reassembly of papillomavirus...

Details In vitro method for disassembly/reassembly of papillomavirus... In vitro method for disassembly/reassembly of papillomavirus...

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 47/48 (2006.01) C07K 14/025 (2006.01) C12N 15/88 (2006.01)

Patent

CA 2302545

A method of disassembly/reassembly of papillomavirus VLPs is provided. The resultant VLPs have enhanced homogeneity, present conformational, neutralizing PV epitopes, and therefore are useful prophylactic and diagnostic agents. Further, these VLPs can be used to encapsulate desired moieties, e.g., therapeutic or diagnostic agents, or "marker" DNAs, and the resultant VLPs used as in vivo delivery vehicles or as pseudovirions for evaluating vaccine efficacy.

L'invention concerne une méthode de désassemblage-réassemblage de particules voroïdes du papillomavirus. Les VLP ainsi obtenues présentent une homogénéité accrue, ainsi que des épitopes de papillomavirus neutralisants, conformationnels, et constituent, par conséquent, des agents prophylactiques et diagnostiques utiles. En outre, on peut utiliser ces VLP pour encapsuler des fractions voulues, par exemple, des agents thérapeutiques ou diagnostiques, ou des AND "marqueurs", et les VLP obtenues utilisées comme vecteurs d'administration in vivo ou comme pseudovirions permettant d'évaluer l'efficacité d'un vaccin.

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