G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) G01N 33/576 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2718126
The present invention relates to the field of virology. More precisely, the invention provides a method of determining the ability of a test compound to modulate the biological activity of a variant of a target protein, wherein said test compound is previously known to modulate the biological activity of said protein. This invention is useful to determine whether a drug candidate, such as anti-viral compounds (eg. against hepatitis C virus: NS5B, NS3), active against a target protein is active against a variant of said protein (eg. polymorphisms, genotypes or mutants).
La présente invention porte sur le domaine de la virologie. Plus précisément, l'invention porte sur un procédé consistant à déterminer l'aptitude d'un composé de test à moduler l'activité biologique d'un variant d'une protéine cible, ledit composé de test étant précédemment connu pour moduler l'activité biologique de ladite protéine. Cette invention est utile pour déterminer si un médicament candidat, tel que des composés antiviraux (par exemple, contre le virus de l'hépatite C : NS5B, NS3), actif contre une protéine cible, est actif contre un variant de ladite protéine (par exemple, des polymorphismes, génotypes ou mutants).
Lahmar Medhi
Mehtali Majid
Valarche Isabelle
Goudreau Gage Dubuc
Vivalis
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