C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 48/00 (2006.01) A61L 27/00 (2006.01) A61P 43/00 (2006.01) C12N 5/02 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/87 (2006.01) G01N 33/00 (2006.01)
Patent
CA 2464460
Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro- organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation.
L'invention se rapporte à des cultures de micro-organes comprenant des populations isolées de cellules possédant des caractéristiques spécifiques. Les cultures de micro-organes de l'invention présentent notamment la particularité de pouvoir être maintenues en culture sur de relativement longues périodes, ainsi que de préserver une microarchitecture d'organe qui facilite, par exemple, des interactions cellule-cellule et cellule-matrice analogues à celles survenant dans l'organe source. Les cultures de micro-organes de l'invention peuvent être utilisées dans des procédés destinés à fournir des produits génétiques à des sujets receveurs, à identifier des agents de prolifération cellulaire et de différenciation cellulaire, et à identifier et isoler des cellules souches. De plus, les cultures de micro-organes de la présente invention peuvent être utilisées dans des procédés d'identification d'inhibiteurs de la prolifération cellulaire, de la différenciation cellulaire et de l'infectiosité virale. Dans d'autres modes de réalisation, les cultures de micro-organes peuvent servir à la transplantation.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Yissum Research Development Company Of The Hebrew University Of
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