In vitro production of dendritic cells from cd14+ monocytes

Details In vitro production of dendritic cells from cd14+ monocytes In vitro production of dendritic cells from cd14+ monocytes

C - Chemistry, Metallurgy

12

N

C12N 5/0784 (2010.01) C12N 5/071 (2010.01) C12N 5/0786 (2010.01) A61K 35/14 (2006.01) C12N 5/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2469792

The invention relates to the use of CD14+ monocytes for the production of dendritic cells. The invention comprises the use of CD14+ monocytes isolated from peripheral circulating blood for obtaining, by differentiation, at least one mixed population of Langerhans cells and interstitial dendritic cells, both Langerhans cells and interstitial dendritic cells being preconditioned and undifferentiated, and/or differentiated and immature, and/or mature, and/or interdigitated. The invention comprises their use in suspension, monolayer and three-dimensional cell and tissue models. The invention comprises the use of these cells and of these models as study models for the assessment of immunotoxicity/immunotolerance, for the development of cosmetic and pharmaceutical active principles and for the development and implementation of methods of cell and tissue therapy.

L'invention concerne l'utilisation de monocytes CD14?+¿ pour la production de cellules dendritiques. L'invention comprend l'utilisation de monocytes CD14?+¿ isolés à partir de sang de circulation périphérique, pour obtenir, par différenciation au moins une population mélangée de cellules de Langerhans et de cellules dendritiques interstitielles, à la fois les cellules de Langerhans et les cellules dendritiques interstitielles étant préconditionnées et indifférenciées, et/ou différenciées, et non mûres et/ou mûres, et/ou interdigitées. L'invention concerne l'utilisation de modèles tissulaires et cellulaires tridimensionnels et monocouches. L'invention concerne l'utilisation de ces cellules et de ces modèles en tant que modèles d'études pour évaluer l'immunotoxicité/l'immunotolérance, pour le développement de principes actifs cosmétiques et pharmaceutiques, et pour le développement et la mise en oeuvre de procédés de thérapie cellulaire et tissulaire.

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