C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/04 (2006.01) C12Q 1/00 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2478529
The invention relates to an in vitro serological method of diagnosing infective endocarditis with negative hemoculture caused by Coxellia burnetii and Bartonella sp bacteria in a patient with a cardiac valve disorder. The inventive method is characterised in that it consists in: dosing IgG-type antibodies of the phase I Coxellia burnetii bacterium and IgG-type antibodies of a Bartonella sp bacterium onto one same serum of a patient, and determining if the titre of said IgG antibodies is greater than or equal to 1/800?th¿.
La présente invention est relative à une méthode de diagnostic sérologique in vitro des endocardites infectieuses à hémoculture négative causées par les bactéries Coxellia burnetii et Bartonella sp chez un malade atteint d'une affection des valves cardiaques, caractérisée en ce qu'on réalise un dosage des anticorps de type IgG de la bactérie Coxellia burnetii de phase I et des anticorps de type IgG d'une bactérie Bartonella sp, sur un même sérum d'un dit malade, et on détermine si le titre desdits anticorps IgG est supérieur ou égal à 1/800 ?ème¿.
Goudreau Gage Dubuc
Universite de La Mediterranee (aix-Marseille Ii)
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