In vitro t-lymphopoiesis system

Details In vitro t-lymphopoiesis system In vitro t-lymphopoiesis system

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 35/14 (2006.01) A61K 35/26 (2006.01) A61K 35/28 (2006.01) A61K 38/20 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2206449

The present invention provides an in vitro T-lymphopoiesis system in which a population of T-cells is produced from precursor cells expressing CD34. The T- lymphopoiesis system of the present invention produces a population of T-cells of which approximately 17-74 % express CD2, approximately 1.5-34 % express CD3, and approximately 16-61 % express CD4, and approximately 0-15 % express CD8. A method of producing such a population of T-cells in vitro, as well as various compositions including T-cells of the present invention, are also provided.

La présente invention concerne un système de lymphopoïèse de lymphocytes T in vitro dans lequel une population de lymphocytes T est obtenue à partir de cellules précurseurs exprimant CD34. Ce système de lymphopoïèse de lymphocytes T produit une population de lymphocytes T dont environ 17 à 74 % expriment CD2, environ 1,5 à 34 % expriment CD3, environ 16 à 61 % expriment CD4 et environ 0 à 15 % expriment CD8. L'invention concerne également un procédé de production d'une telle population de lymphocytes T in vitro, ainsi que différentes compositions contenant des lymphocytes T produits conformément à la présente invention.

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