In vitro tissue and organ equivalent models

Details In vitro tissue and organ equivalent models In vitro tissue and organ equivalent models

C - Chemistry, Metallurgy

12

N

C12N 5/06 (2006.01) A61F 2/14 (2006.01) A61K 35/12 (2006.01) A61L 27/38 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) C12Q 1/18 (2006.01)

Patent

CA 2204869

This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model on the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro. This invention is also directed to the use of endothelial cells in other tissue and organ equivalents to promote basement membrane development.

La présente invention concerne un équivalent organique de la cornée de l'oeil réalisé à l'aide de systèmes de mise en culture de tissus. Ce procédé de réalisation de l'équivalent de la cornée permet d'obtenir une structure analogue à la cornée de l'oeil in vivo. Cet équivalent cornéen est un modèle in vitro de l'oeil, qui s'utilise pour la transplantation ou l'implantation in vivo ou pour le criblage de composés in vitro. La présente invention concerne également l'emploi de cellules endothéliales dans d'autres équivalents tissulaires et organiques pour accélérer le développement de la membrane basale.

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