In vivo binding pair pretargeting

Details In vivo binding pair pretargeting In vivo binding pair pretargeting

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2107558

2107558 9317707 PCTABS00025 A method for in vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog.

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