In vivo cellular tracking

Details In vivo cellular tracking In vivo cellular tracking

A - Human Necessities

61

K

167/46

A61K 49/00 (2006.01) C12Q 1/04 (2006.01) G01N 33/52 (2006.01)

Patent

CA 1294545

ABSTRACT OF THE DISCLOSURE Methods of tracking cells in vivo and for determining in vivo cell lifetimes. Cells are labelled with cyanine dyes and detection is by measuring fluorescence, absorbance, or by detecting nuclear magnetic reasonance probes included in the cyanine dyes. Using the invented methods, for example, red blood cell and platelet lifetimes are determined. Also, cells are tracked to determine sites of primary or metastatic tumors, or sites of occult infection. Further, rates at which cells pass through vessels is used to determine blood vessel patency and platelet aggregation.

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