In vivo delivery of active factors by co-cultured cell implants

Details In vivo delivery of active factors by co-cultured cell implants In vivo delivery of active factors by co-cultured cell implants

C - Chemistry, Metallurgy

12

N

C12N 11/04 (2006.01) A61K 9/00 (2006.01) A61K 9/66 (2006.01) A61K 35/12 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12P 1/00 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2090719

Methods and devices are disclosed for the delivery of an active factor from an implanted co-culture of an active factor-sec- reting cell obtained from a first source and an augmentary substance-secreting cell obtained from a second source different from the first source to a target region in a subject. The co-culture is maintained within a biocompatible, semipermeable membrane in which the augmentary substance secreted by the augmentary substance-producing cells stimulates the active factor-producing cells to secrete active factor. The semipermeable membrane permits the diffusion of the active factor therethrough while excluding detrimental agents present in the external environment from gaining access to the co-culture.

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