In vivo delivery of neurotransmitters by implanted,...

Details In vivo delivery of neurotransmitters by implanted,... In vivo delivery of neurotransmitters by implanted,...

A - Human Necessities

61

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167/104, 167/117

A61K 9/22 (2006.01) A61F 2/02 (2006.01) A61K 9/00 (2006.01) A61K 9/50 (2006.01) A61K 35/12 (2006.01) A61M 31/00 (2006.01) B01J 13/02 (2006.01) C12M 3/00 (2006.01) C12N 5/00 (2006.01) C12N 5/06 (2006.01) C12N 11/00 (2006.01) C12N 11/04 (2006.01)

Patent

CA 1335715

Methods and devices are disclosed for the delivery of a neurotransmitter from an implanted, neurotransmitter-secreting cell culture to a target region in a subject. The cell culture is maintained within a biocompatible, semipermeable membrane which permits the diffusion of the neurotransmitter therethrough while excluding viruses, antibodies, and other detrimental agents present in the external environment from gaining access. Implantable cell culture devices are disclosed, some of which may be retrieved from the subject, replaced or recharged with new, neurotransmitter-secreting cell cultures, and reimplanted.

583385

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