In vivo detection of biomolecule concentrations using...

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01) A61K 49/00 (2006.01) G01N 21/64 (2006.01)

Patent

CA 2429127

Methods are disclosed wherein labeled antibodies can be provided in vivo to tissue having antigens that specifically bind the labeled antibody. A first optical radiation is emitted into the tissue in vivo to excite the labeled antibody bound to the antigen in vivo. A second optical radiation that is emitted by the excited labeled antibody, in response to the excitation thereof, can be detected in vivo. Related telemetric circuits and compositions of matter are also disclosed.

L'invention concerne des procédés qui permettent de fournir <i>in vivo</i> des anticorps étiquetés à des tissus ayant des antigènes qui lient spécifiquement l'anticorps étiqueté. Un premier rayonnement optique est émis à l'intérieur du tissu <i>in vivo</i> de façon à exciter l'anticorps lié à l'antigène <i>in vivo</i>. Un second rayonnement, émis par l'anticorps étiqueté excité, en réaction à l'excitation de celui-ci, peut être détecté <i>in vivo</i>. L'invention concerne également des circuits télémétriques et des compositions de matière.

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