C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/29 (2006.01) A61K 47/42 (2006.01) A61K 48/00 (2006.01) C12N 15/18 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2251655
The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.
Procédé in vivo destiné au ciblage spécifique et au transfert d'ADN dans des cellules de réparation mammaliennes. L'ADN transféré peut comprendre tout ADN codant une protéine thérapeutique d'intérêt. La présente invention est fondée sur la découverte selon laquelle les cellules de réparation mammaliennes prolifèrent et migrent dans un site de blessure où elles absorbent et expriment activement l'ADN. Elle concerne encore des compositions pharmaceutiques qui peuvent être utilisées dans l'application de la présente invention pour transférer l'ADN d'intérêt. Lesdites compositions comportent toute matrice appropriée en combinaison avec l'ADN d'intérêt.
Bonadio Jeffrey
Goldstein Steven A.
Osler Hoskin & Harcourt Llp
The Regents Of The University Of Michigan
LandOfFree
In vivo gene transfer methods for wound healing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with In vivo gene transfer methods for wound healing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and In vivo gene transfer methods for wound healing will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1787745