In vivo imaging of apoptosis

Details In vivo imaging of apoptosis In vivo imaging of apoptosis

A - Human Necessities

61

K

A61K 49/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 21/64 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2479938

The invention relates to conjugates and methods for in vivo imaging of apoptosis using conjugates of fluorochromes and moieties that bind specifically to apoptotic cells. In specific embodiments, the fluorochrome emits fluorescence in the near-infrared range and is conjugated to a moiety, e.g., a protein such as annexin A5 or synaptotagmin, that binds specifically to apoptotic cells. The methods are non-invasive can be used to obtain images of apoptotic cells in the tissues of living animals, e.g., mammals such as humans.

L'invention concerne des conjugués et des procédés destinés à l'imagerie <i>in vivo</i> de l'apoptose utilisant des conjugués de fluorochromes et de groupes fonctionnels qui se lient spécifiquement aux cellules apoptotiques. Dans des modes de réalisation spécifiques, le fluorochrome émet une fluorescence dans une gamme de l'infrarouge proche et est conjugué à un groupe fonctionnel, par exemple, à une protéine telle que l'annexine A5 ou synaptotagmine qui se lie spécifiquement aux cellules apoptotiques. Les procédés, non invasifs, peuvent s'utiliser pour obtenir des images de cellules apoptotiques dans les tissus des animaux vivants, par exemple, de mammifères tels que les humains.

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