C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) C12N 1/21 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2580840
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate alkynyl amino acids such as para- propargyloxyphenylalanine into proteins produced in a eubacteria host such as E. coli. The invention provides novel orthoghonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing alkynyl amino acids, and cellular translation systems.
L'invention porte sur des paires orthogonales d'ARNt et sur des synthétases aminoacyl-ARNt qui comprennent des acides aminés d'alkynyle tels que para-propargyloxyphénylalanine dans des protéines produites dans un hôte d'eubactéries tel que E. coli . L'invention porte également sur de nouvelles synthétases orthogonales, sur leurs procédés d'identification et de fabrication, sur des procédés de production des protéines contenant des acides aminés d'alkynyle et sur des systèmes de translation cellulaires.
Deiters Alexander
Schultz Peter
Fetherstonhaugh & Co.
The Scripps Research Institute
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