In vivo induction for enhanced function of isolated hepatocytes

Details In vivo induction for enhanced function of isolated hepatocytes In vivo induction for enhanced function of isolated hepatocytes

C - Chemistry, Metallurgy

12

N

C12N 5/16 (2006.01) C12N 5/071 (2010.01) A61K 31/00 (2006.01) A61K 35/407 (2006.01) C12P 1/00 (2006.01) A61K 35/12 (2006.01) C12M 3/00 (2006.01) C12N 9/10 (2006.01)

Patent

CA 2378893

The invention features a liver cell culture comprising hepatocytes that have increased detoxification enzyme activity when isolated from a liver of a donor that had been administered at least one induction agent prior isolation of hepatocyte cells. The induced hepatocytes are used in a bioreactor and cultured to produce hepatocyte cell products or metabolize toxins added to the culture. The bioreactor is, or is an integral part of, a liver assist device used to treat a patient in need of liver assist.

L'invention concerne une culture de cellules hépatiques possédant une activité enzymatique de détoxication accrue lorsqu'elles sont isolées dans le foie d'un donneur auquel au moins un agent d'induction a été administré avant l'isolation des cellules hépatocytaires. Les hépatocytes induits sont utilisés dans un bioréacteur et sont mis en culture, de manière que des produits de cellules hépatocytaires soient obtenus, ou des toxines métabolisées sont ajoutées à la culture. Le bioréacteur est un dispositif d'assistance hépatique ou fait partie intégrante d'un dispositif de ce type, utilisé pour le traitement d'un patient ayant besoin d'une assistance hépatique.

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