G - Physics – 01 – K
Patent
G - Physics
01
K
324/1
G01K 7/00 (2006.01) G01R 33/48 (2006.01) G01R 33/563 (2006.01)
Patent
CA 1322220
Abstract of the Disclosure A method of determining and imaging the temper- ature or the temperature change of an object (human, animal, liquid or solid) by nuclear magnetic resonance of molecular diffusion coefficients is disclosed which includes placing the object in a magnetic field Bo at a temperature To, subjecting the object to a first series of magnetic resonance imaging sequences to obtain first numerical values or images of molecular diffusion coefficients Do for individual points of the object or of a limited volume thereof, changing the temperature to a temperature T of a part of the object measured in step (b), or waiting for a spontaneous change to said temper- ature, subjecting the object to a second series of mag- netic resonance imaging sequences to obtain second numerical values or images of molecular diffusion coefficients D for individual points of the object or of a limited volume thereof, comparing point-by point the values of the diffusion coefficients Do allocated for the first series of diffusion images obtained in step (b) with the values of the diffusion coefficients D obtained in the second series of diffusion images in step (d) to determine and to generate a third series of values or images representing temperature changes dT between steps (b) and (d) for each individual point i of the object or of a limited volume thereof from the formula dTi = (kTo2/E) Log (D/Do)i wherein k is Boltzman's constant (1.38 10-23 J/K) and E is the activation energy (?0.2 eV at 20°C), provided dT <<To and E constant, repeating steps (c) to (e) continu- ously for different points of the object so that tempera- ture changes dTi can be monitored continuously, determining the absolute temperature To for individual points of the entire object or a limited volume thereof so that by repeating steps (b) to (f) the absolute temperature T can be determined and imaged continuously in each point of the object or of a limited volume thereof from the formula T = To + dTi wherein dT is determined and imaged in step (e). Because of the non-invasive, non-destructive and non-ionizing properties of nuclear magnetic resonance the present invention may be employed in an object or an animal con- tinuously.
608802
Delannoy Jose
Lebihan Denis
Levin Ronald L.
Delannoy Jose
Gowling Lafleur Henderson Llp
Lebihan Denis
Levin Ronald L.
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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