In vivo model for immunocomparability

Details In vivo model for immunocomparability In vivo model for immunocomparability

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A01K 67/027 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2549248

The present invention relates to methods for determining the relative immunogenicity of exogenous antibody variants comprising a) creating a non- human animal, which is transgenic for a standard antibody, b) contacting said transgenic non-human animal with an exogenous antibody whereby said exogenous antibody is a variant of said transgenic standard antibody of a), and c) determining the immune response of the transgenic non-human animal elicited by the exogenous antibody of (b).

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