A - Human Necessities – 61 – B
Patent
A - Human Necessities
61
B
A61B 6/00 (2006.01) A61B 5/00 (2006.01) A61K 49/00 (2006.01) G01N 21/64 (2006.01) A61B 5/107 (2006.01)
Patent
CA 2427014
The present invention is directed to a method of detecting a neurodegenerative disease in a mammal by activating brain tissue of the mammal by application of radiation under conditions effective to promote a simultaneous multiphoton excitation of the brain tissue and to emit a fluorescence characteristic. The fluorescence characteristic is then compared to a standard fluorescence emitted by exciting healthy brain tissue of the mammal under the same conditions used to carry out the activating step. Brain tissue where the fluorescence characteristic differs from the standard fluorescence is identified as potentially having a neurodegenerative disease. Another aspect of the present invention is directed to a method of producing an image of brain tissue from a mammal by activating brain tissue of a mammal with radiation applied under conditions effective to promote a simultaneous multiphoton excitation of the brain tissue and to produce fluorescence. The fluorescence is then collected to produce an image of the brain tissue.
L'invention concerne un procédé de détection d'une maladie neurodégénérative chez un mammifère par activation du tissu cérébral de ce dernier par application d'un rayonnement dans des conditions efficaces afin de favoriser une excitation multiphotonique simultanée du tissu cérébral et d'émettre une caractéristique de fluorescence. Cette caractéristique de fluorescence est ensuite comparée à une fluorescence standard émise par excitation du tissu cérébral sain d'un mammifère dans les mêmes conditions que celles utilisées lors de l'étape d'activation. Les parties du tissu cérébral au niveau desquelles la caractéristique de fluorescence diffère de la fluorescence standard sont identifiées comme susceptibles d'être atteintes d'une maladie neurodégénérative. Un autre aspect de l'invention concerne un procédé de production d'une image du tissu cérébral d'un mammifère par activation de ce tissu par application d'un rayonnement dans des conditions efficaces afin de favoriser une excitation multiphotonique simultanée du tissu cérébral et de produire la fluorescence. Cette fluorescence est ensuite recueillie afin de produire une image du tissu cérébral.
Bacskai Brian
Christie Richard
Hyman Bradley T.
Webb Watt W.
Zipfel Warren R.
Cornell Research Foundation Inc.
Gowling Lafleur Henderson Llp
The General Hospital Corporation D/b/a Massachusetts General Hos
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