In vivo polymerizable ophthalmic compositions

Details In vivo polymerizable ophthalmic compositions In vivo polymerizable ophthalmic compositions

A - Human Necessities

61

K

A61K 31/19 (2006.01) A61K 31/16 (2006.01) A61K 31/22 (2006.01) A61K 31/25 (2006.01) A61K 31/755 (2006.01) A61K 31/765 (2006.01) A61L 27/34 (2006.01) A61L 31/10 (2006.01) A61P 27/02 (2006.01) A61K 31/78 (2006.01) A61K 31/785 (2006.01)

Patent

CA 2272625

Ophthalmic compositions containing biocompatible, bioadhesive polymerizable amphipathic mesophase materials useful for repairing retinal tissue tears or retinal detachments are disclosed. In one embodiment, the polymerizable materials, which comprise substituted fluoroalkyl or perfluoroalkyl monomers having anionic, cationic, and/or nonionic surface active functionality in the unsaturated fluorophobic ends, are polymerized in vivo to provide effective, long-lasting repair of torn, ruptured or detached retinal tissue. Ophthalmic applications of these materials are not limited to retinal repair.

Cette invention se rapporte à des compositions ophtalmiques contenant des substances mésophases amphipathiques polymérisables bioadhésives et biocompatibles, servant à réparer les déchirements des tissus de la rétine ou les décollements de rétine. Dans un mode de réalisation, ces substances polymérisables, qui renferment des monomères fluoroalkyle ou perfluoroalkyle substitués présentant des fonctions d'agents tensioactifs anionique, cationique et/ou non ionique dans les extrémités fluorophobes insaturées, sont polymérisées in vivo pour assurer une réparation efficace de longue durée des tissus de la rétine déchirés, rompus ou décollés. Les applications ophtalmiques de ces substances ne sont pas limitées à la réparation de la rétine.

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